Survival Bias in Mendelian Randomization Studies
نویسندگان
چکیده
منابع مشابه
Avoiding bias from weak instruments in Mendelian randomization studies.
BACKGROUND Mendelian randomization is used to test and estimate the magnitude of a causal effect of a phenotype on an outcome by using genetic variants as instrumental variables (IVs). Estimates of association from IV analysis are biased in the direction of the confounded, observational association between phenotype and outcome. The magnitude of the bias depends on the F-statistic for the stren...
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In Mendelian randomization (MR) studies, where genetic variants are used as proxy measures for an exposure trait of interest, obtaining adequate statistical power is frequently a concern due to the small amount of variation in a phenotypic trait that is typically explained by genetic variants. A range of power estimates based on simulations and specific parameters for two-stage least squares (2...
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ژورنال
عنوان ژورنال: Epidemiology
سال: 2019
ISSN: 1044-3983
DOI: 10.1097/ede.0000000000001072